Leon

Celaya

Valle de Santiago

Irapuato

Yuriria

Pénjamo

Manuel Doblado

Silao

Purísima del Rincón

San Francisco del Rincón

Salamanca

![aerial photo of dome building under blue sky at daytime](https://images.unsplash.com/photo-1547686669-9a8cb1a22d91?ixlib=rb-4.0.3&ixid=M3wxMjA3fDB8MHxzZWFyY2h8NHx8bWV4aWNvJTIwY2l0eXxlbnwwfHwwfHx8MA%3D%3D&w=1000&q=80)
 Mexico is one of the largest Latin American markets, with a massive population that gives its startup ecosystems an advantage in the ability to scale locally. Mexico also enjoys strategic access to both the North American and South American markets. As a result, it has become home to some of the region’s most successful startups, including unicorns like Kavak, Clip, and Bitso, which collectively highlight the country's innovation potential. Plata also joined the unicorn club in early 2025, reinforcing the continued momentum of Mexico’s startup ecosystem. 

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 Global economic shifts further accelerate this momentum. The US-China trade war and supply chain disruptions during the pandemic lead many multinationals to relocate their production facilities and engineering centers to Mexico, boosting innovation and economic growth in the country. While many economies face rising US tariffs during this period, Mexico retains preferential access to the US market through the United States-Mexico-Canada Agreement (USMCA), although some sectors—such as automobiles and steel—remain subject to additional tariffs. 

 Mexico provides startups with various sources of investment funding, as well as an environment with low operating costs. The public sector supports startup ecosystem growth through several national initiatives. The government is directly involved in both local and regional ecosystems through programs such as Startup México, which includes various initiatives for startups, SMEs, and corporations focused on boosting innovation. Another forward-thinking government initiative is the Fintech Law, which fills regulatory gaps and provides clarity for firms operating in legal gray areas. 

 Mexican ecosystems also receive support from local governments. For instance, Chihuahua strengthens its ecosystem through Ecosistema De Impacto Social (EDIS), under the Municipality of Chihuahua, which backs social entrepreneurship initiatives. One of the most impressive efforts was launched in 2020 by the Guanajuato State Government, which introduced a public strategy to promote entrepreneurship and brand the state as the Valley de la Mentefactura. The Instituto de Innovación, Ciencia y Emprendimiento para la Competitividad is a key stakeholder in the region and organizes Manufactura Day to promote local innovation. 

 Public sector efforts are complemented by global recognition from world-class investors. Sequoia Capital, Andreessen Horowitz, and 500 Global are all actively looking to invest in Mexico’s growing startup ecosystems. This shows that top investors recognize Mexico’s potential and that the ongoing efforts of ecosystem developers are paying off.

Mexico

This innovative health-tech app serves as a digital pharmacy, seamlessly connecting users with a wide range of medicines from distributors, labs, pharmacies, and supermarkets. It ensures convenient delivery straight to their chosen location, prioritizing exceptional service and user experience in the wellness journey.

iSana Health

iSana Health startup from Leon, Mexico is ranked 105917 out of 193933 worldwide and 556 from the 1113 startups in Mexico. See more information and additional rankings on the StartupBlink Global Ecosystem Map

As the innovation hub of the region, Leon is renowned for its outstanding high-tech R&D capacity, highly-trained professionals, and thriving networks of entrepreneurs which enable our  startup ecosystem to achieve steady continuous growth.

Guanajuato

In the recent years, Guanajuato has become a gravity centre for the most talented people not only from Mexico, but from all over the world. Such concentration of professionals affirms guanajuato as one of the global “cities of the future”, world centre for the development of breakthrough technologies, particularly in IT.

The Moscow Agency of Innovations was established to create a truly favorable environment for the advancement of technology in Moscow.

2016

The Skolkovo Innovation Center and Skolkovo Foundation was signed into law with a goal to goal is to create a sustainable ecosystem of entrepreneurship and innovation.

2010

Avito, a classified ads website and now a unicorn, first went online.

2007

The Moscow Seed Fund, a VC which invests in see and pre-seed startups, was established.

2005

Yandex search engine was launched!!!!

1997

Guanajuato earns the 2nd Prize in Fab City Awards with its innovation strategy, Mindfacture Valley.

2023

The launch of the first Capital Startup Capital Summit together entrepreneurs, investors, and business leaders to discuss and promote investment opportunities within the region.

2021

The first Mentefactura Day in Guanajuato, an event dedicated to fostering innovation and entrepreneurship.

2020

Creation of the Institute of Innovation, Science and Entrepreneurship for Competitiveness (IDEA GTO)

iSana Health Startup Info & Ecosystem Rankings | StartupBlink